| Drug notes |
| Inhibits fibrinolysis, therefore can be used to reduce bleeding |
| Use |
| Indications |
| Suspected bleeding in the context of major trauma (excluding isolated head injury) where the patient has either a heart rate >110 or systolic BP <90 |
| Cautions |
| • known allergy to Tranexamic acid |
| Dose 1 – within 3hrs of incident |
| • Adults: 1g IV/IO over 10 mins • Children: 15mg/kg IV/IO over 10 mins (max 1g) |
| Dose 2 – during 8hrs following incident |
| • Adults: 1g IV at 60ml/hr over 8hrs • Children: 2mg/kg/hr over 8 hours |
| Special groups |
| • No evidence of harm in pregnancy |
| Side effects |
| • Nausea, vomiting • Hypotension on rapid injection |
| Filler text |
| Filler text to pad out the box, FIller text |
| Presentation |
| 500mg in 5ml, glass vial (100mg/ml) |
| Administration – dose 1 |
| Required volume (dose) into 100ml 5% dextrose (in trauma bag) or 100ml N/Saline. Administer IV/IO over 5–10 mins |
| Administration – dose 2 |
| 1g tranexamic acid in 500ml of N/Saline over 8hrs at rate of 60ml/hr. |
| Drug information |
|
Not a controlled drug Can be kept at room temperature |
| Further information |
| BNF: section 2.11 |