11.d.i • Propofol

The MTC Outreach Service advocates the use of standard infusions for the transfer of patients to the MTC, detailed later (adapted from Magpas).

Transfer service

Drug notes
Propofol 2% (20mg/ml)
Hypnotic agent used for the maintenance of anaesthesia and sedation for ventilation or other procedures, 20mg per ml.

Use
Indications
• As an infusion for maintenance of sedation and anaesthesia in ventilated patients


Cautions
• Elderly
• Hypovolaemia
• Cardiovascular disease
All predispose to hypotension and risk circulatory collapse
Dose (1ml = 20mg)
• Adults: 1– 4mg/kg/hr (0–20ml/hr)
• Children: 1– 4mg/kg/hr
• Titrate to blood pressure
• Adult bolus: 1–2mls
Special groups
• Safe in pregnancy
• Safe in children for short term use
Side effects
• Hypotension (negatively inotropic and vasodilatory)
• Apnoea
Presentation: 50ml vial, white emulsion
Transfer Service uses only 2% solutions 1% solutions are available in hospitals
Double-check strength prior to use Use only 2%
Administration
Only given as an infusion using an approved infusion pump.


Storage and stock
No special storage requirements

Drug information
Not a controlled drug
Can be kept at room temperature

Further information
BNF: section 15.1.1